Effect of mint drink on metabolism of nicotine as measured by nicotine to cotinine ratio in urine of Jordanian smoking volunteers.

What Was Tested

The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.

The purpose of this research was to evaluate mint drink effect on nicotine metabolism as judged by nicotine/cotinine ratio in urine of Jordanian smokers.

Why It Was Studied

Variation in nicotine metabolism may be due to genetic alterations in CYP 2A6, environmental factors, and diet.

Who Took Part

By PubMed's age tags, the people studied were young adults, adults and middle-aged adults, both men and women.

Twenty-four Jordanian smoker volunteers were allocated randomly into two groups.

One group treatment sequence was mint drink, off-menthol, while the other group treatment was off-menthol, mint drink.

How the Study Was Run

The design is described as randomized and crossover.

Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Each person switched between Therapeutic nicotine (patch, non-peptide) and the comparison at some point, usually with a gap in between.

Early morning urine samples were collected at baseline and at the end of each period.

Samples were analyzed by liquid chromatography-mass spectrometry for the nicotine and cotinine concentrations.

Nicotine/cotinine ratio was calculated and compared among the different periods for each participant using the paired t test.

What Was Measured

PubMed files the paper under topics including Beverages, Chromatography, High Pressure Liquid, Cotinine, Drinking Behavior, Jordan, Mass Spectrometry and Mentha piperita.

What This Means in Plain Language

The paper is a randomized and crossover study of Therapeutic nicotine (patch, non-peptide).

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2011 (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco), a journal based in England.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.