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Effects of propofol on intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism undergoing parathyroidectomy: a randomized control trial
Plain-language guide to PMID 21455643 (2011): randomized controlled trial study of Parathyroid Hormone (PTH 1-84), hyperparathyroidism.
Key Facts
- PMID
- 21455643
- Journal
- Canadian journal of anaesthesia = Journal canadien d'anesthesie
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Kivela JE et al. (8 authors)
- DOI
- 10.1007/s12630-011-9496-4
What This Study Did, in Plain Language
What Was Tested
Researchers studied Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism in this randomized controlled trial publication.
Serial measurements of parathyroid hormone (PTH) serum concentrations aid parathyroidectomy surgery.
The primary purpose of this study is to determine the effects of propofol on PTH concentrations in patients with primary hyperparathyroidism and to determine its effect on PTH assays.
Who Took Part
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
Thirty patients with primary hyperparathyroidism were assigned randomly to induction and maintenance with either propofol or sevoflurane.
How the Study Was Run
The researchers set it up as a randomized study.
The participants were allocated by chance, so the Parathyroid Hormone (PTH 1-84) group and the comparison group should start out alike.
Blood samples for PTH assays were obtained pre-induction, immediately after induction, ten minutes after induction, and after excision of parathyroid adenoma.
The primary endpoint was the PTH concentration at ten minutes after induction.
This endpoint was compared between groups using analysis of covariance adjusting for pre-induction PTH.
Serum PTH was measured in duplicate in each sample and analyzed using repeated measures analysis of variance.
What Was Measured
The subject headings attached to it are Anesthetics, Intravenous, Hyperparathyroidism, Primary, Monitoring, Intraoperative, Parathyroid Hormone, Parathyroidectomy and Propofol.
What This Means in Plain Language
The paper is a randomized study of Parathyroid Hormone (PTH 1-84) in people with hyperparathyroidism.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2011 (Canadian journal of anaesthesia = Journal canadien d'anesthesie), a journal based in United States.
More context: the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.