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Modulation of aldosterone release by epidural analgesia impacts brain natriuretic peptide: a link to stress cardiomyopathy? Pilot study
Plain-language guide to PMID 21470289 (2011): open-label randomized controlled trial study of BNP (Nesiritide).
Key Facts
- PMID
- 21470289
- Journal
- Clinical endocrinology
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Radović M et al. (6 authors)
- DOI
- 10.1111/j.1365-2265.2011.03971.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at BNP (Nesiritide).
This study was designed to compare whether the modulation of intra-operative aldosterone release by epidural analgesia had an effect on the brain natriuretic peptide (BNP) levels.
Who Took Part
By PubMed's age tags, the people studied were middle-aged adults, men only.
Patients were randomized to one of two anaesthesia protocols: group 1 included 13 patients who received general anaesthesia, and group 2 included 12 patients who received combined general anaesthesia and epidural analgesia.
How the Study Was Run
The design is described as randomized, open-label and pilot.
Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Everyone knew when BNP (Nesiritide) was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.
It is described as a pilot, a small early test of whether a larger BNP (Nesiritide) study would be practical.
A study was pilot prospective, open label randomized one.
Serum aldosterone, BNP, cortisol (measured by radioimmunoassay), adrenocorticotropine hormone (ACTH) (by solid-phase ELSA), blood chemistry, complete blood count and vital signs were compared preoperatively, intra-operatively and at postoperative days (POD) 1 and 7.
What Was Measured
The subject headings attached to it are Aldosterone, Analgesia, Epidural, Anesthesia, General, Heart Diseases, Natriuretic Peptide, Brain, Perioperative Period and Pilot Projects.
What This Means in Plain Language
The paper is a randomized, open-label and pilot study of BNP (Nesiritide).
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2011 (Clinical endocrinology), a journal based in England.
More context: the BNP (Nesiritide) compound page, all human trials.
Our Notes on the Compound
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.