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Cobalamin status modifies the effect of zinc supplementation on the incidence of prolonged diarrhea in 6- to 30-month-old north Indian children.
Plain-language guide to PMID 21525251 (2011): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12) in 2296 children.
Key Facts
- PMID
- 21525251
- Journal
- The Journal of nutrition
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Manger MS et al. (9 authors)
- DOI
- 10.3945/jn.110.127415
- Registered trial
- NCT00272116
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
In a randomized, double-blind trial in 2296 children in New Delhi, India, the researchers assessed whether baseline cobalamin or folate status modified the effect of zinc supplementation on the incidence of prolonged (≥ 7 d duration) and acute diarrhea.
Who Took Part
The abstract describes 2296 children taking part.
The age groups tagged for this paper are infants and young children, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the children and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
In a randomized, double-blind trial in 2296 children in New Delhi, India, the researchers assessed whether baseline cobalamin or folate status modified the effect of zinc supplementation on the incidence of prolonged (≥ 7 d duration) and acute diarrhea.
Topics PubMed links to this paper include Diarrhea, Dietary Supplements, Folic Acid, Homocysteine, Incidence, India and Methylmalonic Acid.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12) in 2296 children.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2011 (The Journal of nutrition), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compounds
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.