Relationship of adiponectin to endogenous GH pulse secretion parameters in response to stimulation with a growth hormone releasing factor

What Was Tested

The paper reports a study of GHRH (Growth Hormone-Releasing Hormone), published as a clinical trial.

However, the relationship between adiponectin and parameters of endogenous GH secretion remains unknown.

The aim of this study was to determine the relationship between total and high molecular weight (HMW) adiponectin and parameters of endogenous pulsatile GH secretion and the effects of tesamorelin, a synthetic GH releasing hormone (GHRH(1-44)), on total and HMW adiponectin.

Overnight frequent blood sampling and measurement of total and HMW adiponectin at baseline and after treatment were performed to assess the effects of augmenting endogenous pulsatile GH secretion.

Who Took Part

The abstract describes 13 men taking part.

The age groups tagged for this paper are teenagers, adults and middle-aged adults, men only.

A 2-week interventional study with tesamorelin was conducted at an academic medical center in 13 men with BMI 20-35 kg/m(2).

What Was Measured

Topics PubMed links to this paper include Adiponectin, Growth Hormone-Releasing Hormone, Human Growth Hormone and Obesity.

What This Means in Plain Language

This is a clinical trial of GHRH (Growth Hormone-Releasing Hormone) in 13 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2011 (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society), a journal based in Scotland.

More context: the GHRH (Growth Hormone-Releasing Hormone) compound page, all human trials.