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Effects of weight loss on serum vitamin D in postmenopausal women.
Plain-language guide to PMID 21613554 (2011): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 21613554
- Journal
- The American journal of clinical nutrition
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Mason C et al. (16 authors)
- DOI
- 10.3945/ajcn.111.015552
- Registered trial
- NCT00470119
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations.
Why It Was Studied
Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese.
Who Took Part
The age groups tagged for this paper are middle-aged adults and older adults, women only.
Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87).
How the Study Was Run
The design is described as randomized.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo.
What Was Measured
Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese.
PubMed files the paper under topics including Caloric Restriction, Exercise, Postmenopause, Sunlight, Vitamin D and Weight Loss.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2011 (The American journal of clinical nutrition), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.