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Effects of tolvaptan on physician-assessed symptoms and signs in patients hospitalized with acute heart failure syndromes: analysis from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan (EVEREST) trials.
Plain-language guide to PMID 21641352 (2011): randomized controlled trial of Benzazepines in 4,133 patients.
Key Facts
- PMID
- 21641352
- Journal
- American heart journal
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Pang PS et al. (12 authors)
- DOI
- 10.1016/j.ahj.2011.02.027
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Benzazepines, published as a randomized controlled trial.
A rapid and sustained relief of heart failure (HF) symptoms and signs is an important goal of management in patients hospitalized for acute HF syndromes (AHFS).
Why It Was Studied
This study explores the clinical effects of tolvaptan, a vasopressin-2-receptor antagonist, in addition to standard medical therapies on physician-assessed signs and symptoms in hospitalized AHFS patients.
Who Took Part
The study group was 4,133 patients.
By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.
On each inpatient day, investigators assessed dyspnea, orthopnea, fatigue, jugular venous distension (JVD), rales, and pedal edema by predefined ordinal scales.
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this Benzazepines study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
This study explores the clinical effects of tolvaptan, a vasopressin-2-receptor antagonist, in addition to standard medical therapies on physician-assessed signs and symptoms in hospitalized AHFS patients.
Topics PubMed links to this paper include Antidiuretic Hormone Receptor Antagonists, Benzazepines, Heart Failure and Tolvaptan.
What This Means in Plain Language
The paper is a randomized study of Benzazepines in 4,133 patients.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2011 (American heart journal), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.