The effects of morphine-neostigmine and secretin provocation on pancreaticobiliary morphology in healthy subjects: a randomized, double-blind crossover study using serial MRCP

What Was Tested

This randomized controlled trial paper looks at Secretin.

The aim of the present study was to use serial MRCP to characterize the effects of morphine-neostigmine and secretin provocation on serum pancreatic enzyme responses and pancreaticobiliary ductal morphology in healthy subjects.

Why It Was Studied

Secretin-stimulated magnetic resonance cholangiopancreatography (MRCP) is used for the diagnosis of sphincter of Oddi dysfunction (SOD), but it does not correlate well with sphincter of Oddi manometry.

Who Took Part

The abstract describes 10 subjects taking part.

The age groups tagged for this paper are young adults, adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind and crossover study.

The subjects were allocated by chance, so the Secretin group and the comparison group should start out alike.

As a double-blind Secretin study, the assignments were hidden from both participants and investigators until the end.

Each person switched between Secretin and the comparison at some point, usually with a gap in between.

A MRCP study was performed at 5, 30, 60, 90, 120, 150, and 180 min thereafter, with blood samples taken every 60 min for 4 h.

Pancreatic duct (PD) diameter, visible PD length, common bile duct (CBD) diameter, and gallbladder volume were recorded.

Crossover studies were performed 10 days later.

What Was Measured

PubMed files the paper under topics including Cholangiopancreatography, Magnetic Resonance, Common Bile Duct, Morphine, Neostigmine, Pain Measurement, Pancreatic Ducts and Pancreatic Function Tests.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Secretin in 10 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2011 (World journal of surgery), a journal based in United States.

More context: the Secretin compound page, all human trials.