← Human Trials & Peer-Reviewed Studies
Vitamin D and intestinal calcium absorption.
Plain-language guide to PMID 21664413 (2011): review of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 21664413
- Journal
- Molecular and cellular endocrinology
- Year
- 2011
- Study type
- Review
- Authors
- Christakos S et al. (5 authors)
- DOI
- 10.1016/j.mce.2011.05.038
What This Paper Covers, in Plain Language
What It Covers
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a review.
Calcium is absorbed by both an active transcellular pathway, which is energy dependent, and by a passive paracellular pathway through tight junctions. 1,25Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) the hormonally active form of vitamin D, through its genomic actions, is the major stimulator of active intestinal calcium absorption which involves calcium influx, translocation of calcium through the interior of the enterocyte and basolateral extrusion of calcium by the intestinal plasma membrane pump.
This article reviews recent studies that have challenged the traditional model of vitamin D mediated transcellular calcium absorption and the crucial role of specific calcium transport proteins in intestinal calcium absorption.
Who the Included Studies Covered
PubMed tags the participants as women only.
What Was Measured
Calcium is absorbed by both an active transcellular pathway, which is energy dependent, and by a passive paracellular pathway through tight junctions. 1,25Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) the hormonally active form of vitamin D, through its genomic actions, is the major stimulator of active intestinal calcium absorption which involves calcium influx, translocation of calcium through the interior of the enterocyte and basolateral extrusion of calcium by the intestinal plasma membrane pump.
This article reviews recent studies that have challenged the traditional model of vitamin D mediated transcellular calcium absorption and the crucial role of specific calcium transport proteins in intestinal calcium absorption.
Topics PubMed links to this paper include Age Factors, Aging, Biological Transport, Calcium, Estrogens, Glucocorticoids and Homeostasis.
What This Means in Plain Language
This is a review of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2011 (Molecular and cellular endocrinology), a journal based in Ireland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.