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Haemodynamic effect of triglycyl-lysine-vasopressin (glypressin) on intravascular oesophageal variceal pressure in patients with cirrhosis. A randomized placebo controlled trial
Plain-language guide to PMID 2185299 (1990): double-blind randomized controlled trial study of Vasopressin and Terlipressin in 20 patients.
Key Facts
- PMID
- 2185299
- Journal
- Journal of hepatology
- Year
- 1990
- Study type
- Randomized Controlled Trial
- Authors
- Cestari R et al. (5 authors)
- DOI
- 10.1016/0168-8278(90)90053-t
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vasopressin and Terlipressin, published as a randomized controlled trial.
Experimental protocol required two basal intravascular oesophageal variceal pressure (IOVP) measurements, before and after bolus i.v. drug injection.
Other measurements were taken 1, 3, 5 and 10 min after drug administration.
Who Took Part
According to the abstract, 20 patients were involved.
The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the patients and researchers unaware of who received Vasopressin.
The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.
What Was Measured
Experimental protocol required two basal intravascular oesophageal variceal pressure (IOVP) measurements, before and after bolus i.v. drug injection.
Other measurements were taken 1, 3, 5 and 10 min after drug administration.
PubMed files the paper under topics including Blood Pressure, Esophageal and Gastric Varices, Liver Cirrhosis, Lypressin, Randomized Controlled Trials as Topic and Terlipressin.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Terlipressin in 20 patients.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1990 (Journal of hepatology), a journal based in Netherlands.
More context: the Vasopressin compound page and the Terlipressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Terlipressin: A synthetic vasopressin analog (Terlivaz) used for kidney failure in advanced liver disease and for variceal bleeding.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.