Mode of death and hospitalization from the Second Follow-up Serial Infusions of Nesiritide (FUSION II) trial and comparison of clinical events committee adjudicated versus investigator reported outcomes

What Was Tested

The paper reports a study of BNP (Nesiritide), published as a randomized controlled trial.

FUSION II was a randomized, double-blind, placebo-controlled trial evaluating outpatient nesiritide infusions versus placebo, with 911 patients with advanced HF (New York Heart Association class III or IV) and renal dysfunction enrolled.

Who Took Part

According to the abstract, 911 patients were involved.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind BNP (Nesiritide) study, the assignments were hidden from both participants and investigators until the end.

Some patients received a placebo instead of BNP (Nesiritide), giving a reference point.

What Was Measured

FUSION II was a randomized, double-blind, placebo-controlled trial evaluating outpatient nesiritide infusions versus placebo, with 911 patients with advanced HF (New York Heart Association class III or IV) and renal dysfunction enrolled.

PubMed files the paper under topics including Cause of Death, Clinical Trials Data Monitoring Committees, Heart Failure, Hospitalization, Infusion Pumps, Natriuretic Agents and Natriuretic Peptide, Brain.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of BNP (Nesiritide) in 911 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

The publication is from 2011 (The American journal of cardiology), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.