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Effect of low-dose human atrial natriuretic peptide on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer: a double-blind, placebo-controlled study
Plain-language guide to PMID 21992849 (2012): double-blind randomized controlled trial study of ANP (Atrial Natriuretic Peptide) in 40 patients.
Key Facts
- PMID
- 21992849
- Journal
- The Journal of thoracic and cardiovascular surgery
- Year
- 2012
- Study type
- Randomized Controlled Trial
- Authors
- Nojiri T et al. (7 authors)
- DOI
- 10.1016/j.jtcvs.2011.09.003
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ANP (Atrial Natriuretic Peptide).
This study evaluated the effects of human atrial natriuretic peptide on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer.
Who Took Part
The study group was 40 patients.
By PubMed's age tags, the people studied were middle-aged adults, older adults and people over 80, both men and women.
A prospective, randomized study was conducted with 40 patients who had preoperative elevated B-type natriuretic peptide (≥ 30 pg/mL) and underwent a scheduled pulmonary resection for lung cancer.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got ANP (Atrial Natriuretic Peptide) and who got the comparison, which limits bias.
As a double-blind ANP (Atrial Natriuretic Peptide) study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the ANP (Atrial Natriuretic Peptide) group a baseline to be compared against.
The primary end point was the incidence of postoperative atrial fibrillation during the first 4 days after surgery.
What Was Measured
PubMed files the paper under topics including Analysis of Variance, Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Natriuretic Factor, Biomarkers, C-Reactive Protein and Chi-Square Distribution.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ANP (Atrial Natriuretic Peptide) in 40 patients.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2012 (The Journal of thoracic and cardiovascular surgery), a journal based in United States.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.