Effect of dialysate calcium concentrations on parathyroid hormone and calcium balance during a single dialysis session using bicarbonate hemodialysis: a crossover clinical trial

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this randomized controlled trial publication.

In bicarbonate-based hemodialysis, dialysate total calcium (tCa) concentration may have effects on mineral metabolism.

Small sample size and lack of measurement of total-body calcium mass balances.

Who Took Part

The study group was 22 patients.

By PubMed's age tags, the people studied were middle-aged adults, both men and women.

22 stable anuric uremic patients underwent three 4-hour bicarbonate hemodialysis sessions with the 3 different dialysate tCa concentrations using a single-pass batch dialysis system.

How the Study Was Run

The researchers set it up as a randomized and crossover study.

Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the patients took both Parathyroid Hormone (PTH 1-84) and the comparison in turn, acting as their own control.

Randomized crossover trial of 3 dialysate tCa concentrations (2.5, 2.75, and 3.0 mEq/L).

What Was Measured

Small sample size and lack of measurement of total-body calcium mass balances.

Topics PubMed links to this paper include Bicarbonates, Calcium, Dialysis Solutions, Parathyroid Hormone and Renal Dialysis.

What This Means in Plain Language

The paper is a randomized and crossover study of Parathyroid Hormone (PTH 1-84) in 22 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2012 (American journal of kidney diseases : the official journal of the National Kidney Foundation), a journal based in United States.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.