Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.

To test the effect of 25(OH)D(3) (HyD) compared to vitamin D(3) on serum 25-hydroxyvitamin D levels (25(OH)D), lower extremity function, blood pressure, and markers of innate immunity.

Why It Was Studied

All analyses were adjusted for baseline measurement, age, and body mass index.

This rise was immediate and sustained.

Who Took Part

PubMed indexes the participants as middle-aged adults and older adults, women only.

How the Study Was Run

The design is described as randomized and double-blind.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

At baseline and at 4 months, a test battery for lower extremity function (knee extensor and flexor strength, timed up and go, repeated sit-to-stand) was assessed.

What Was Measured

All analyses were adjusted for baseline measurement, age, and body mass index.

PubMed files the paper under topics including Biomarkers, Blood Glucose, Blood Pressure, Calcifediol, Calcium, Cholecalciferol and Dietary Supplements.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in people with low blood pressure and orthostatic hypotension.

The publication is from 2012 (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.