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Calcium supplementation lowers serum parathyroid hormone levels in elderly subjects
Plain-language guide to PMID 2203847 (1990): double-blind randomized controlled trial study of Parathyroid Hormone (PTH 1-84) in 40 volunteers.
Key Facts
- PMID
- 2203847
- Journal
- Journal of gerontology
- Year
- 1990
- Study type
- Randomized Controlled Trial
- Authors
- Kochersberger G et al. (4 authors)
- DOI
- 10.1093/geronj/45.5.m159
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.
To determine the effect of calcium supplementation on parathyroid hormone levels (PTH) in a group of elderly subjects at risk for developing Type II (senile) osteoporosis, 40 healthy volunteers participated in a randomized double-blind crossover study.
Why It Was Studied
Calcium carbonate or placebo was administered for 4 weeks, followed by a 4-week administration of the alternative intervention.
Fasting blood samples and 24-hour urine collections were obtained at baseline, and at the end of each intervention period.
Who Took Part
According to the abstract, 40 volunteers were involved.
PubMed tags the participants as both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the volunteers and researchers unaware of who received Parathyroid Hormone (PTH 1-84).
A placebo (an inactive look-alike) gave the Parathyroid Hormone (PTH 1-84) group a baseline to be compared against.
Each person switched between Parathyroid Hormone (PTH 1-84) and the comparison at some point, usually with a gap in between.
The timeline in the abstract includes 4 weeks.
What Was Measured
PubMed files the paper under topics including Aging, Calcium, Creatinine, Parathyroid Hormone and Randomized Controlled Trials as Topic.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Parathyroid Hormone (PTH 1-84) in 40 volunteers over 4 weeks.
The publication is from 1990 (Journal of gerontology), a journal based in United States.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.