Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The researchers sought to find genetic factors that might interact with vitamin D levels to affect the risk of asthma exacerbation.

Who Took Part

The abstract describes 403 subjects taking part.

PubMed indexes the participants as children, both men and women.

The researchers conducted a genome-wide study of gene-vitamin D interaction on asthma exacerbations using population-based and family-based approaches on 403 subjects and trios from the Childhood Asthma Management Program.

How the Study Was Run

The design is described as randomized and double-blind.

The subjects were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

Topics PubMed links to this paper include Asthma, Gene Expression, Gene-Environment Interaction, Genome-Wide Association Study, Genotype, Immunoglobulins and Polymorphism, Single Nucleotide.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 403 subjects.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2012 (The Journal of allergy and clinical immunology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.