← Human Trials & Peer-Reviewed Studies
Chaperones CCS, ATOX and COXIV responses to copper supplementation in healthy adults
Plain-language guide to PMID 22124795 (2012): placebo-controlled randomized controlled trial study of Copper (Supplement).
Key Facts
- PMID
- 22124795
- Journal
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
- Year
- 2012
- Study type
- Randomized Controlled Trial
- Authors
- Araya M et al. (4 authors)
- DOI
- 10.1007/s10534-011-9511-9
What This Study Did, in Plain Language
What Was Tested
Researchers studied Copper (Supplement) in this randomized controlled trial publication.
The aim of this study was to assess by means of an in vitro challenge the mRNA relative abundance of ccs, sod1, coxIV, mtIIa and atox in peripheral mononuclear cells (PMNCs) obtained from healthy individuals, acutely and chronically supplemented with small-to-moderate amounts of copper.
Why It Was Studied
Assessment of proteins in blood and other tissues has failed to identify markers of early copper effects on health.
Studies in animal models show that chaperone of SOD (CCS) respond to changes of copper status.
Who Took Part
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized and placebo-controlled study.
The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.
A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.
Biochemical indicators were assessed at basal (T0) and after 2 (T2) and 60 days (T60).
What Was Measured
Assessment of proteins in blood and other tissues has failed to identify markers of early copper effects on health.
At these times PMNCs were obtained, challenged with 1, 5 or 20 μM Cu-histidine for 20 h and the mRNA relative abundance of the selected genes assessed by real time PCR.
The subject headings attached to it are Cation Transport Proteins, Copper, Copper Transport Proteins, Dietary Supplements, Electron Transport Complex IV, Leukocytes, Mononuclear and Metallochaperones.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Copper (Supplement).
The publication is from 2012 (Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine), a journal based in Netherlands.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.