Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Vascular calcification is a predictor of cardiovascular morbidity and mortality.

Hemodialysis patients experience severe vascular calcifications.

Who Took Part

The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, both men and women.

53 long-term hemodialysis patients in stable conditions, 18 years or older. 50 healthy age-matched individuals served as controls.

How the Study Was Run

In design terms this was a randomized, single-blind, placebo-controlled and parallel-group study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Only one side, usually the participants, was kept unaware of whether Vitamin D, K2, Magnesium and Zinc was given.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Groups ran in parallel: each of the participants stayed in one arm throughout.

Interventional randomized non-placebo-controlled trial with 3 parallel groups.

Plasma levels were assessed using enzyme-linked immunosorbent assays.

What Was Measured

PubMed files the paper under topics including Biomarkers, Calcium-Binding Proteins, Comorbidity, Dietary Supplements, Disease Progression, Extracellular Matrix Proteins and Kidney Diseases.

What This Means in Plain Language

The paper is a randomized, single-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2012 (American journal of kidney diseases : the official journal of the National Kidney Foundation), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.