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Effects of exercise and B vitamins on homocysteine and glutathione in Parkinson's disease: a randomized trial
Plain-language guide to PMID 22261439 (2012): randomized controlled trial study of Glutathione, parkinson's disease.
Key Facts
- PMID
- 22261439
- Journal
- Neuro-degenerative diseases
- Year
- 2012
- Study type
- Randomized Controlled Trial
- Authors
- DiFrancisco-Donoghue J et al. (6 authors)
- DOI
- 10.1159/000333790
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Glutathione in the context of parkinson's disease, published as a randomized controlled trial.
This experiment tested the effects of exercise and B vitamin supplementation on homocysteine and glutathione levels, and if a relationship was present between these two markers in those with PD.
Secondary aims included examining the impact of the interventions on aerobic efficiency and strength.
Who Took Part
The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.
Thirty-six subjects were randomly assigned to 4 groups.
Subjects were tested prior to and after intervention on the following measures: glutathione and homocysteine levels, strength measures and oxygen consumption.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got Glutathione and who got the comparison, which limits bias.
The methods mention a period of 6 weeks.
The Vit group received vitamins B(6), B(12) and folic acid daily for 6 weeks.
The Ex group received aerobic and strength training twice weekly for 6 weeks.
The Vit + Ex group received both interventions.
A control group received no intervention.
What Was Measured
This experiment tested the effects of exercise and B vitamin supplementation on homocysteine and glutathione levels, and if a relationship was present between these two markers in those with PD.
Secondary aims included examining the impact of the interventions on aerobic efficiency and strength.
PubMed files the paper under topics including Analysis of Variance, Exercise Therapy, Glutathione, Glutathione Disulfide, Homocysteine, Parkinsonian Disorders and Vitamin B Complex.
What This Means in Plain Language
The paper is a randomized study of Glutathione in people with parkinson's disease over 6 weeks.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2012 (Neuro-degenerative diseases), a journal based in Switzerland.
More context: the Glutathione compound page, Parkinson's disease research.
Our Notes on the Compound
Glutathione: The body's main antioxidant.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.