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Inconsistent effects of iron-folic acid and/or zinc supplementation on the cognitive development of infants.
Plain-language guide to PMID 22283033 (2011): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 367 infants.
Key Facts
- PMID
- 22283033
- Journal
- Journal of health, population, and nutrition
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Siegel EH et al. (7 authors)
- DOI
- 10.3329/jhpn.v29i6.9896
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Despite concerns over the neurocognitive effects of micronutrient deficiencies in infancy, few studies have examined the effects of micronutrient supplementation on specific cognitive indicators.
This study investigated, in 2002, the effects of iron-folic acid and/or zinc supplementation on the results of Fagan Test of Infant Intelligence (FTII) and the A-not-B Task of executive functioning among 367 Nepali infants living in Sarlahi district.
Who Took Part
The abstract describes 367 infants taking part.
The age groups tagged for this paper are infants, both men and women.
How the Study Was Run
The design is described as randomized and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
This study investigated, in 2002, the effects of iron-folic acid and/or zinc supplementation on the results of Fagan Test of Infant Intelligence (FTII) and the A-not-B Task of executive functioning among 367 Nepali infants living in Sarlahi district.
At 39 and 52 weeks, 247 and 333 infants respectively attempted the cognitive tests; 213 made an attempt to solve both the tests.
Topics PubMed links to this paper include Child Development, Cluster Analysis, Cognition, Dietary Supplements, Folic Acid, Iron and Nepal.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 367 infants.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2011 (Journal of health, population, and nutrition), a journal based in Bangladesh.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.