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Ulipristal acetate versus leuprolide acetate for uterine fibroids
Plain-language guide to PMID 22296076 (2012): double-blind randomized controlled trial study of Leuprolide in 307 patients.
Key Facts
- PMID
- 22296076
- Journal
- The New England journal of medicine
- Year
- 2012
- Study type
- Randomized Controlled Trial
- Authors
- Donnez J et al. (13 authors)
- DOI
- 10.1056/NEJMoa1103180
- Registered trial
- NCT00740831
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Leuprolide, published as a randomized controlled trial.
Who Took Part
According to the abstract, 307 patients were involved.
PubMed indexes the participants as young adults, adults and middle-aged adults, women only.
How the Study Was Run
The design is described as randomized and double-blind.
Random assignment meant chance, not the researchers, decided who got Leuprolide and who got the comparison, which limits bias.
As a double-blind Leuprolide study, the assignments were hidden from both participants and investigators until the end.
What Was Measured
PubMed files the paper under topics including Endometrium, Intention to Treat Analysis, Leiomyoma, Leuprolide, Menorrhagia, Norpregnadienes and Uterine Neoplasms.
What This Means in Plain Language
The paper is a randomized and double-blind study of Leuprolide in 307 patients.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2012 (The New England journal of medicine), a journal based in United States.
More context: the Leuprolide compound page, all human trials.
Our Notes on the Compound
Leuprolide: A 9-amino-acid GnRH analog (Lupron, Eligard) that lowers sex-hormone levels with ongoing use; used in prostate cancer, endometriosis and early puberty.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.