Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women.

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.

The effect of dietary weight loss and exercise training lifestyle interventions was examined on hormones as well as determining their relationships with physical function in older obese and overweight adults.

Who Took Part

PubMed indexes the participants as older adults, both men and women.

Older (≥60 yrs) overweight and obese (BMI≥28 kg/m(2)) adults with knee osteoarthritis (n=309) were recruited for the study.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.

Clinical research setting with facility based exercise and nutrition education and behavior classrooms.

Exercise groups trained (mostly walking and resistance training) 3 days/week for 60 min/session.

Body weight, growth hormone (GH), corticosterone, sex-hormone binding globulin (SHBG), testosterone, and dehydroepiandrosterone (DHEA) were measured at baseline, 6, and 18 months.

Physical function was determined through performance task (6-min walking distance) and self-reported questionnaires (Western Ontario McMaster University Osteoarthritis Index-WOMAC) at similar time points.

What Was Measured

PubMed files the paper under topics including Aging, Dehydroepiandrosterone, Human Growth Hormone, Hydrocortisone, Nutritional Sciences, Obesity and Overweight.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2012 (The journal of nutrition, health & aging), a journal based in France.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.