The alteration of aspart insulin pharmacodynamics when mixed with detemir insulin

What Was Tested

The paper reports a study of Insulin Aspart and Insulin Detemir, published as a randomized controlled trial.

Mixing rapid acting insulin analogs with detemir insulin to minimize daily injections has been adopted as a common regimen, especially for some children with type 1 diabetes, despite the manufacturing company's caution against mixing these analogs in the same syringe.

This crossover, randomized study was undertaken to determine whether mixing aspart with detemir insulin has an adverse effect on the early glucodynamic action of rapid-acting insulin analog in humans.

Who Took Part

PubMed indexes the participants as children, teenagers and young adults, both men and women.

How the Study Was Run

In design terms this was a randomized and crossover study.

Because people in this Insulin Aspart study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the participants took both Insulin Aspart and the comparison in turn, acting as their own control.

What Was Measured

The subject headings attached to it are Blood Glucose, Diabetes Mellitus, Type 1, Drug Combinations, Drug Interactions, Glucose, Hypoglycemic Agents and Infusion Pumps.

What This Means in Plain Language

The paper is a randomized and crossover study of Insulin Aspart and Insulin Detemir.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2012 (Diabetes care), a journal based in United States.

More context: the Insulin Aspart compound page and the Insulin Detemir compound page.