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Circulating ghrelin and GLP-1 are not affected by habitual diet
Plain-language guide to PMID 22387702 (2012): clinical trial study of Ghrelin in 8, participants.
Key Facts
- PMID
- 22387702
- Journal
- Regulatory peptides
- Year
- 2012
- Study type
- Clinical Trial
- Authors
- Ellis AC et al. (6 authors)
- DOI
- 10.1016/j.regpep.2012.02.001
What This Study Did, in Plain Language
What Was Tested
This clinical trial paper looks at Ghrelin.
This study was designed to examine whether 8-week habituation to diets with different percentages of carbohydrate and fat would affect serum ghrelin, GLP-1, and subjective hunger in a postabsorptive state and in response to a standard liquid mixed meal.
Blood was sampled before the meal and at 15, 60, 90, 120, 180, and 240 min to determine total serum ghrelin and active GLP-1.
Mixed models were used to evaluate whether the temporal patterns of total serum ghrelin and active GLP-1 differed with diet.
Why It Was Studied
Ghrelin and glucagon-like peptide-1 (GLP-1) are gut hormones known to induce hunger and satiety, respectively.
Current knowledge about the effects of different macronutrients on circulating ghrelin and GLP-1 comes mainly from acute test meals, whereas little is known about the effects of chronic dietary intake on gut hormone secretion.
Who Took Part
According to the abstract, 8, participants were involved.
The age groups tagged for this paper are young adults, adults and middle-aged adults, both men and women.
How the Study Was Run
Hunger was assessed by a visual analog scale.
What Was Measured
Current knowledge about the effects of different macronutrients on circulating ghrelin and GLP-1 comes mainly from acute test meals, whereas little is known about the effects of chronic dietary intake on gut hormone secretion.
PubMed files the paper under topics including Diet, Feeding Behavior, Gastrointestinal Hormones, Ghrelin and Glucagon-Like Peptide 1.
What This Means in Plain Language
This is a clinical trial of Ghrelin in 8, participants.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
Its findings take up roughly 2 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2012 (Regulatory peptides), a journal based in Netherlands.
More context: the Ghrelin compound page, all human trials.
Our Notes on the Compound
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.