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A prospective evaluation of quick intraoperative parathyroid hormone assay at the time of skin closure in predicting clinically relevant hypocalcemia after thyroidectomy
Plain-language guide to PMID 22399155 (2012): clinical trial study of Parathyroid Hormone (PTH 1-84) in 117 patients.
Key Facts
- PMID
- 22399155
- Journal
- World journal of surgery
- Year
- 2012
- Study type
- Clinical Trial
- Authors
- Lang BH et al. (3 authors)
- DOI
- 10.1007/s00268-012-1561-9
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a clinical trial.
Univariate and multivariate analyses were performed to evaluate potential preoperative clinicopathologic factors and postoperative day 0 biochemical indicators.
Why It Was Studied
Post-thyroidectomy hypocalcemia is a major contributing factor in delayed hospital discharge and dissuading surgeons from ambulatory thyroidectomy.
The researchers prospectively evaluated the accuracy and reliability of quick parathyroid hormone level measurement at skin closure (PTH-SC) in predicting clinically relevant hypocalcemia (i.e., patients requiring calcium ± calcitriol supplements on hospital discharge).
Who Took Part
According to the abstract, 117 patients were involved.
The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults, older adults and people over 80, both men and women.
How the Study Was Run
Serum calcium was checked regularly in the perioperative period until stabilization and an additional quick PTH was checked on the following morning (PTH-D1).
What Was Measured
The researchers prospectively evaluated the accuracy and reliability of quick parathyroid hormone level measurement at skin closure (PTH-SC) in predicting clinically relevant hypocalcemia (i.e., patients requiring calcium ± calcitriol supplements on hospital discharge).
PubMed files the paper under topics including Biomarkers, Decision Support Techniques, Hypocalcemia, Intraoperative Care, Multivariate Analysis, Parathyroid Hormone and Postoperative Complications.
What This Means in Plain Language
This is a clinical trial of Parathyroid Hormone (PTH 1-84) in 117 patients.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2012 (World journal of surgery), a journal based in United States.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.