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Improvement of vitamin D status via daily intake of fortified yogurt drink either with or without extra calcium ameliorates systemic inflammatory biomarkers, including adipokines, in the subjects with type 2 diabetes.

Plain-language guide to PMID 22442277 (2012): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 90 subjects.

Key Facts

PMID
22442277
Journal
The Journal of clinical endocrinology and metabolism
Year
2012
Study type
Randomized Controlled Trial
Authors
Neyestani TR et al. (9 authors)
DOI
10.1210/jc.2011-3465
Registered trial
NCT01229891

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The aim of this study was to investigate the effects of vitamin D either with or without extra calcium on certain inflammatory biomarkers in the subjects with type 2 diabetes (T2D).

Why It Was Studied

Systemic inflammation is thought to have a central role in diabetic long-term complications.

Who Took Part

The study group was 90 subjects.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized and double-blind.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

PubMed files the paper under topics including Adiponectin, Biomarkers, Calcium, Dietary, Cells, Cultured, Cytokines, Diabetes Mellitus, Type 2 and Food, Fortified.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 90 subjects.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2012 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.