Effects of progressive muscular relaxation training on anxiety, depression and quality of life of endometriosis patients under gonadotrophin-releasing hormone agonist therapy

Plain-language guide to PMID 22455972 (2012): open-label randomized controlled trial study of Leuprolide, endometriosis.

Key Facts

PMID: 22455972
Journal: European journal of obstetrics, gynecology, and reproductive biology
Year: 2012
Study type: Randomized Controlled Trial
Authors: Zhao L et al. (6 authors)
DOI: 10.1016/j.ejogrb.2012.02.029

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Leuprolide in the context of endometriosis, published as a randomized controlled trial.

To explore the effects of progressive muscle relaxation (PMR) training on anxiety, depression and quality of life (QOL) of endometriosis patients under gonadotrophin-releasing hormone (GnRH) agonist therapy.

Who Took Part

The age groups tagged for this paper are teenagers, young adults, adults and middle-aged adults, women only.

One hundred consecutive Han Chinese endometriosis patients, aged 18-48 years, were randomly assigned to a PMR group (n=50) and a control group (n=50).

Health-related QOL was measured with SF-36 instrument.

How the Study Was Run

The researchers set it up as a randomized and open-label study.

Because people in this Leuprolide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Being open-label, the Leuprolide study did not mask who received what.

This was a controlled, randomized, open-label study.

In addition to the GnRH agonist therapy, the PMR group received 12 weeks of PMR training.

Anxiety level was measured using the state-trait anxiety inventory (STAI).

Depression was assessed using subscale D of the hospital anxiety and depression scale (HADS-D).

The patients were evaluated with STAI, HADS-D and SF-36 before and after the PMR intervention.

What Was Measured

PubMed files the paper under topics including Anxiety, Depression, Endometriosis, Exercise Therapy, Gonadotropin-Releasing Hormone, Leuprolide and Muscle Relaxation.

What This Means in Plain Language

The paper is a randomized and open-label study of Leuprolide in people with endometriosis.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2012 (European journal of obstetrics, gynecology, and reproductive biology), a journal based in Ireland.

More context: the Leuprolide compound page, Endometriosis research.

Our Notes on the Compound

Leuprolide: A 9-amino-acid GnRH analog (Lupron, Eligard) that lowers sex-hormone levels with ongoing use; used in prostate cancer, endometriosis and early puberty.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.