Effects of vitamin D supplementation on markers of vascular function after myocardial infarction--a randomised controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Groups ran in parallel: each of the participants stayed in one arm throughout.

Parallel group, placebo-controlled, double-blind randomised trial.

Outcomes were measured at baseline, 2 and 6 months.

Reactive hyperaemia index on fingertip plethysmography was the primary outcome.

Secondary outcome measures included blood pressure, cholesterol, C-reactive protein, von Willebrand factor, tumour necrosis factor alpha, E-selectin, B-type natriuretic peptide, thrombomodulin and 25-hydroxyvitamin D levels.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Blood Pressure, Cholesterol, Dietary Supplements, Myocardial Infarction and Vitamin D.

The authors tagged it with the keywords Randomised controlled trial and Vascular.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2013 (International journal of cardiology), a journal based in Netherlands.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.