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Testing for growth hormone deficiency in adults: doing without growth hormone-releasing hormone.

Plain-language guide to PMID 22596248 (2012): review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone).

Key Facts

PMID
22596248
Journal
Current opinion in endocrinology, diabetes, and obesity
Year
2012
Study type
Review
Authors
Kargi AY et al. (2 authors)
DOI
10.1097/MED.0b013e32835430da

What This Paper Covers, in Plain Language

What It Covers

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone) in this review publication.

This article summarizes recent advances in testing for growth hormone deficiency (GHD) in adults, focusing on critical appraisal of existing growth hormone (GH) provocative tests as well as newer tests in development.

Why It Was Studied

Due to the current unavailability of the arginine-GHRH test in the USA, when ITT is contraindicated or impractical the researchers recommend the glucagon stimulation testing as the GH provocative test of choice.

Who the Included Studies Covered

PubMed indexes the participants as adults, both men and women.

What Was Measured

Due to the current unavailability of the arginine-GHRH test in the USA, when ITT is contraindicated or impractical the researchers recommend the glucagon stimulation testing as the GH provocative test of choice.

PubMed files the paper under topics including Arginine, Growth Hormone-Releasing Hormone, Guidelines as Topic, Hypoglycemia, Hypopituitarism, Insulin and Insulin-Like Growth Factor I.

What This Means in Plain Language

This is a review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone).

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2012 (Current opinion in endocrinology, diabetes, and obesity), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the GHRH (Growth Hormone-Releasing Hormone) compound page, all human trials.

Our Notes on the Compounds

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

GHRH (Growth Hormone-Releasing Hormone): The 44-amino-acid hypothalamic hormone that tells the pituitary to release growth hormone; sermorelin and tesamorelin are analogs.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.