Relationship between vitamin D deficiency, bone remodelling and iron status in iron-deficient young women consuming an iron-fortified food.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Their aim was to know whether the consumption of an iron-fortified fruit juice modifies bone remodelling and the possible influence of baseline vitamin D status on the recovery of iron status in a group of iron-deficient women.

Why It Was Studied

Iron and vitamin D deficiencies are two of the most widespread nutritional disorders in the world.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults and adults, women only.

Iron biomarkers, 25-hydroxyvitamin D levels and dietary intake were measured in 123 iron-deficient menstruating women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

A subgroup (n = 41) participated in a randomised double-blind placebo-controlled study of 16-weeks during winter.

They consumed a placebo fruit juice (P) or iron-fortified fruit juice (F).

Dietary intake, 25-hydroxyvitamin D, parathormone (PTH), bone alkaline phosphatase (ALP), aminoterminal telopeptide of collagen I (NTX) and iron biomarkers were determined.

What Was Measured

The subject headings attached to it are Alkaline Phosphatase, Anemia, Iron-Deficiency, Beverages, Biomarkers, Body Mass Index, Bone Remodeling and Energy Intake.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2013 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.