The rhPTH (1-34), but not elcatonin, increases bone anabolic efficacy in postmenopausal women with osteoporosis

What Was Tested

This randomized controlled trial paper looks at Parathyroid Hormone (PTH 1-84) and Calcitonin in the context of osteoporosis and bone density.

This study was to investigate the anabolic effects of rhPTH(1-34) on postmenopausal osteoporosis in an Asian population and compare the time course and alteration in bone turnover marker (BTM) during rhPTH(1-34) and elcatonin treatment.

Who Took Part

The abstract describes 124 women taking part.

The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, women only.

124 women with postmenopausal osteoporosis were enrolled in this prospective, open-label, active-controlled trial.

How the Study Was Run

The researchers set it up as a randomized and open-label study.

Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Everyone knew when Parathyroid Hormone (PTH 1-84) was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Biochemical markers of bone formation (bone specific alkaline phosphatase [BSAP]), and bone resorption maker (serum C-telopeptide of type I collagen [CTX-I] were measured at baseline and at 0, 6, and 12 months.

What Was Measured

Topics PubMed links to this paper include Anabolic Agents, Bone Density, Bone and Bones, Calcitonin, Metabolism, Osteoporosis, Postmenopausal and Parathyroid Hormone.

What This Means in Plain Language

The paper is a randomized and open-label study of Parathyroid Hormone (PTH 1-84) and Calcitonin in 124 women in people with osteoporosis and bone density.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2012 (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association), a journal based in Germany.

More context: the Parathyroid Hormone (PTH 1-84) compound page and the Calcitonin compound page, Osteoporosis and bone density research.