Relationship between the receptor occupancy profile and pleiotropic effects of angiotensin II receptor blockers.

What Was Tested

The paper reports a study of Angiotensin II Type 1 Receptor Blockers, published as a randomized controlled trial.

To investigate whether (i) angiotensin receptor occupying profiles of angiotensin II receptor blockers (ARBs) vary among the drugs and (ii) such differences contribute to the degree of their pleiotropic effects.

Who Took Part

The age groups tagged for this paper are young adults, adults and middle-aged adults, men only.

How the Study Was Run

In design terms this was a randomized, double-blind and crossover study.

The participants were allocated by chance, so the Angiotensin II Type 1 Receptor Blockers group and the comparison group should start out alike.

As a double-blind Angiotensin II Type 1 Receptor Blockers study, the assignments were hidden from both participants and investigators until the end.

In the crossover set-up each of the participants took both Angiotensin II Type 1 Receptor Blockers and the comparison in turn, acting as their own control.

The time course profiles and trough level of receptor occupancy were determined on days 7 and 28, respectively.

The pleiotropic effect related parameters were measured on days 0 and 28 in each trial.

What Was Measured

PubMed files the paper under topics including Angiotensin II Type 1 Receptor Blockers, Antihypertensive Agents, Area Under Curve, Benzimidazoles, Biphenyl Compounds, Blood Pressure and Dinoprost.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Angiotensin II Type 1 Receptor Blockers.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2013 (British journal of clinical pharmacology), a journal based in England.

More context: all human trials.