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High diagnostic accuracy of subcutaneous Triptorelin test compared with GnRH test for diagnosing central precocious puberty in girls
Plain-language guide to PMID 22845185 (2013): randomized controlled trial study of Triptorelin.
Key Facts
- PMID
- 22845185
- Journal
- Clinical endocrinology
- Year
- 2013
- Study type
- Randomized Controlled Trial
- Authors
- Freire AV et al. (7 authors)
- DOI
- 10.1111/j.1365-2265.2012.04517.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Triptorelin.
To evaluate the diagnostic accuracy of Triptorelin test (index test) compared to the GnRH test (reference test) in girls with suspicion of CPP.
Why It Was Studied
The GnRH test is the gold standard to confirm the diagnosis of central precocious puberty (CPP); however, this compound is not always readily available.
Diagnostic accuracy of subcutaneous GnRH analogues tests compared to classical GnRH test has not been reported.
Who Took Part
The age groups tagged for this paper are young children and children, women only.
How the Study Was Run
The researchers set it up as a randomized study.
The participants were allocated by chance, so the Triptorelin group and the comparison group should start out alike.
A prospective, case-control, randomized clinical trial was performed.
CPP or precocious thelarche (PT) was diagnosed according to maximal LH response to GnRH test and clinical characteristics during follow-up.
Gonadotrophins and estradiol responses to Triptorelin test were measured by ultrasensitive assays.
What Was Measured
The GnRH test is the gold standard to confirm the diagnosis of central precocious puberty (CPP); however, this compound is not always readily available.
Diagnostic accuracy of subcutaneous GnRH analogues tests compared to classical GnRH test has not been reported.
The subject headings attached to it are Gonadotropin-Releasing Hormone, Puberty, Precocious, Sensitivity and Specificity and Triptorelin Pamoate.
What This Means in Plain Language
The paper is a randomized study of Triptorelin.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2013 (Clinical endocrinology), a journal based in England.
More context: the Triptorelin compound page, all human trials.
Our Notes on the Compound
Triptorelin: A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.