Effects of naltrexone on smoking cessation outcomes and weight gain in nicotine-dependent men and women.

What Was Tested

The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.

The researchers assessed smoking quit rates and weight gain in a double-blind randomized trial comparing oral naltrexone (n = 162) with placebo (n = 154) in nicotine-dependent participants who wanted to quit smoking.

After this time, participants continued with naltrexone or placebo through 12 weeks.

Who Took Part

PubMed indexes the participants as adults and middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Therapeutic nicotine (patch, non-peptide) and who got the comparison, which limits bias.

As a double-blind Therapeutic nicotine (patch, non-peptide) study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Therapeutic nicotine (patch, non-peptide) could be set against what happens without it.

What Was Measured

The researchers assessed smoking quit rates and weight gain in a double-blind randomized trial comparing oral naltrexone (n = 162) with placebo (n = 154) in nicotine-dependent participants who wanted to quit smoking.

Follow-up assessments were conducted at 26 and 52 weeks.

PubMed files the paper under topics including Cognitive Behavioral Therapy, Combined Modality Therapy, Naltrexone, Narcotic Antagonists, Sex Factors, Smoking Cessation and Tobacco Use Cessation Devices.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).

The publication is from 2012 (Journal of clinical psychopharmacology), a journal based in United States.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.