Endometrial gene expression in the early luteal phase is impacted by mode of triggering final oocyte maturation in recFSH stimulated and GnRH antagonist co-treated IVF cycles

What Was Tested

Researchers studied hCG (human chorionic gonadotropin) and Triptorelin in the context of endometriosis in this randomized controlled trial publication.

Do differences in endometrial gene expression exist after ovarian stimulation with four different regimens of triggering final oocyte maturation and luteal phase support in the same patient?

GnRH agonist triggering is an alternative to hCG triggering in GnRH antagonist co-treated cycles, resulting in an elimination of early ovarian hyperstimulation syndrome.

Who Took Part

The age groups tagged for this paper are adults, women only.

A prospective randomized study was performed in four oocyte donors recruited from an oocyte donation program during the period 2010-2011.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the hCG (human chorionic gonadotropin) group and the comparison group should start out alike.

Four oocyte donors in a university IVF center each prospectively underwent four consecutive stimulation protocols, with different modes of triggering final oocyte maturation and a different luteal phase support, followed by endometrial biopsy on Day 5 after oocyte retrieval.

Microarray data analysis was performed with GeneSpring GX 11.5 (RMA algorithm).

Pathway and network analysis was performed with the gene ontology software Ingenuity Pathways Analysis (Ingenuity® Systems, www.ingenuity.com, Redwood City, CA, USA).

Samples were grouped and background intensity values were removed (cutoff at the lowest 20th percentile).

What Was Measured

Topics PubMed links to this paper include Chorionic Gonadotropin, Endometrium, Fertilization in Vitro, Follicle Stimulating Hormone, Human, Gene Expression Profiling, Gene Expression Regulation and Gonadotropin-Releasing Hormone.

What This Means in Plain Language

The paper is a randomized study of hCG (human chorionic gonadotropin) and Triptorelin in people with endometriosis.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2012 (Human reproduction (Oxford, England)), a journal based in England.

More context: the hCG (human chorionic gonadotropin) compound page and the Triptorelin compound page, Endometriosis research.