Evening versus morning injections of growth hormone (GH) in GH-deficient patients: effects on 24-hour patterns of circulating hormones and metabolites.

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.

Since serum GH in normal subjects displays a circadian variation with a major and consistent surge after the onset of sleep the researchers examined whether the time of GH administration in GH-deficient patients had any impact on its action.

Eight GH-deficient patients all underwent 3 4-week study schedules in random order: 1) evening (2000 h) sc GH injections, 2) morning (0800 h) sc GH injections, and 3) no GH administration.

Who Took Part

The age groups tagged for this paper are children and teenagers, both men and women.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.

What Was Measured

At the end of each period the patients were admitted to hospital for 24-h measurements of hormones and metabolites.

The subject headings attached to it are 3-Hydroxybutyric Acid, Alanine, Blood Glucose, Circadian Rhythm, Dwarfism, Pituitary, Glycerol and Growth Hormone.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 1990 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.