← Human Trials & Peer-Reviewed Studies
Local administration of growth hormone stimulates tendon collagen synthesis in elderly men.
Plain-language guide to PMID 22961272 (2012): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 10 subjects.
Key Facts
- PMID
- 22961272
- Journal
- Journal of applied physiology (Bethesda, Md. : 1985)
- Year
- 2012
- Study type
- Randomized Controlled Trial
- Authors
- Vestergaard P et al. (9 authors)
- DOI
- 10.1152/japplphysiol.00816.2012
What This Study Did, in Plain Language
What Was Tested
Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this randomized controlled trial publication.
In a placebo-controlled, double-blinded study, the researchers examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr).
Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively.
Who Took Part
The abstract describes 10 subjects taking part.
By PubMed's age tags, the people studied were middle-aged adults and older adults, men only.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The subjects were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.
As a double-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study, the assignments were hidden from both participants and investigators until the end.
Some subjects received a placebo instead of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), giving a reference point.
Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured.
What Was Measured
The subject headings attached to it are Collagen, Growth Hormone, Human Growth Hormone, Injections, Insulin-Like Growth Factor I, Microdialysis and Patellar Ligament.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 10 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2012 (Journal of applied physiology (Bethesda, Md. : 1985)), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.