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Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial.
Plain-language guide to PMID 23032549 (2012): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 322 adults.
Key Facts
- PMID
- 23032549
- Journal
- JAMA
- Year
- 2012
- Study type
- Randomized Controlled Trial
- Authors
- Murdoch DR et al. (10 authors)
- DOI
- 10.1001/jama.2012.12505
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
To determine the effect of vitamin D supplementation on incidence and severity of URTIs in healthy adults.
Why It Was Studied
Observational studies have reported an inverse association between serum 25-hydroxyvitamin D (25-OHD) levels and incidence of upper respiratory tract infections (URTIs).
Who Took Part
According to the abstract, 322 adults were involved.
The age groups tagged for this paper are adults and middle-aged adults, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
The adults were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the adults nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
Observational studies have reported an inverse association between serum 25-hydroxyvitamin D (25-OHD) levels and incidence of upper respiratory tract infections (URTIs).
The subject headings attached to it are Absenteeism, Cholecalciferol, Incidence, Respiratory Tract Infections, Risk, Vitamin D and Vitamins.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 322 adults.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2012 (JAMA), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.