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The effect of single-file reciprocating systems on Substance P and Calcitonin gene-related peptide expression in human periodontal ligament
Plain-language guide to PMID 23062064 (2013): randomized controlled trial study of CGRP (Calcitonin Gene-Related Peptide) and Substance P.
Key Facts
- PMID
- 23062064
- Journal
- International endodontic journal
- Year
- 2013
- Study type
- Randomized Controlled Trial
- Authors
- Caviedes-Bucheli J et al. (8 authors)
- DOI
- 10.1111/iej.12005
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of CGRP (Calcitonin Gene-Related Peptide) and Substance P, published as a randomized controlled trial.
To quantify the effect of two single-file reciprocating root canal preparation systems on Substance P (SP) and Calcitonin gene-related peptide (CGRP) expression in healthy human periodontal ligament (PDL).
Who Took Part
By PubMed's age tags, the people studied were teenagers, young adults and adults.
Forty PDL samples were obtained from healthy premolars where extraction was indicated for orthodontic reasons.
The remaining 10 premolars where extracted without treatment and served as a negative control group.
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this CGRP (Calcitonin Gene-Related Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Prior to extraction, 20 of these premolars were divided equally in two groups, and then, root canals were prepared using one of two different single-file systems: WaveOne and Reciproc.
Ten premolars were prepared with hand files and served as a positive control group.
All PDL samples were processed, and SP and CGRP were measured by radioimmunoassay.
What Was Measured
Topics PubMed links to this paper include Bicuspid, Calcitonin Gene-Related Peptide, Equipment Design, Neurotransmitter Agents, Periodontal Ligament, Root Canal Preparation and Substance P.
What This Means in Plain Language
The paper is a randomized study of CGRP (Calcitonin Gene-Related Peptide) and Substance P.
The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2013 (International endodontic journal), a journal based in England.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page and the Substance P compound page, all human trials.
Our Notes on the Compounds
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Substance P: An 11-amino-acid neuropeptide involved in pain signaling and inflammation; given in research studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.