The effect of sea buckthorn supplement on oral health, inflammation, and DNA damage in hemodialysis patients: a double-blinded, randomized crossover study.

What Was Tested

This randomized controlled trial looks at Plant Oils.

The objective of this study was to evaluate effects of sea buckthorn oil (SBO) extract, which is rich in vitamins, phytochemicals, and polyunsaturated fatty acids, on oxidative stress, saliva production, and inflammation in hemodialysis patients.

Who Took Part

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

The study subjects were hemodialysis patients (n = 45) recruited from the Department of Renal Medicine at Karolinska University Hospital in Stockholm.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Random assignment meant chance, not the researchers, decided who got Plant Oils and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Plant Oils, so expectations could not easily colour the readings.

Some participants received a placebo instead of Plant Oils, giving a reference point.

In the crossover set-up each of the participants took both Plant Oils and the comparison in turn, acting as their own control.

This was a randomized, double-blinded, and placebo-controlled crossover study (2 × 8 weeks, 4-week washout).

What Was Measured

Topics PubMed links to this paper include Biomarkers, C-Reactive Protein, Creatinine, DNA Damage, Dietary Supplements, Hippophae and Inflammation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Plant Oils.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2013 (Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation), a journal based in United States.

More context: all human trials.