← Human Trials & Peer-Reviewed Studies
Oral zinc supplementation restores high molecular weight seminal zinc binding protein to normal value in Iraqi infertile men.
Plain-language guide to PMID 23145537 (2012): clinical trial of Vitamin D, K2, Magnesium and Zinc in 37 men.
Key Facts
- PMID
- 23145537
- Journal
- BMC urology
- Year
- 2012
- Study type
- Clinical Trial
- Authors
- Hadwan MH et al. (3 authors)
- DOI
- 10.1186/1471-2490-12-32
- Registered trial
- NCT01612403
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a clinical trial.
Zinc in human seminal plasma is divided into three types of ligands which are high (HMW), intermediate (IMW), and low molecular weight ligands (LMW).
The present study was aimed to study the effect of Zn supplementation on the quantitative and qualitative characteristics of semen along with Zinc Binding Protein levels in the seminal plasma in asthenozoospermic patients.
Who Took Part
According to the abstract, 37 men were involved.
By PubMed's age tags, the people studied were adults, men only.
Semen samples were obtained from 37 fertile and 37 asthenozoospermic infertile men with matched age.
Semen samples were obtained (before and after zinc sulfate supplementation).
How the Study Was Run
After liquefaction seminal fluid at room temperature, routine semen analyses were performed.
For determination of the amount of zinc binding proteins, the gel filtration of seminal plasma on Sephadex G-75 was performed.
All the fractions were investigated for protein and for zinc concentration by atomic absorption spectrophotometry.
Evaluation of chromatograms was made directly from the zinc concentration in each fraction.
What Was Measured
The present study was aimed to study the effect of Zn supplementation on the quantitative and qualitative characteristics of semen along with Zinc Binding Protein levels in the seminal plasma in asthenozoospermic patients.
The subject headings attached to it are Carrier Proteins, Dietary Supplements, Infertility, Male, Iraq, Semen and Zinc Sulfate.
What This Means in Plain Language
This is a clinical trial of Vitamin D, K2, Magnesium and Zinc in 37 men.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2012 (BMC urology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.