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Supplementation with [amount hidden] vitamin D/d leads to parathyroid hormone suppression, but not increased fractional calcium absorption, in 4-8-y-old children: a double-blind randomized controlled trial
Plain-language guide to PMID 23151536 (2013): double-blind randomized controlled trial study of Parathyroid Hormone (PTH 1-84) in 64 children.
Key Facts
- PMID
- 23151536
- Journal
- The American journal of clinical nutrition
- Year
- 2013
- Study type
- Randomized Controlled Trial
- Authors
- Abrams SA et al. (3 authors)
- DOI
- 10.3945/ajcn.112.046102
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.
Stable isotopes were used to assess calcium absorption.
Why It Was Studied
The effects of vitamin D supplementation in healthy prepubertal children on physiologic outcomes have not been investigated.
Who Took Part
According to the abstract, 64 children were involved.
The age groups tagged for this paper are young children and children, both men and women.
The main outcome measure was calcium absorption before and after supplementation.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The children were allocated by chance, so the Parathyroid Hormone (PTH 1-84) group and the comparison group should start out alike.
Neither the children nor the staff measuring them knew who was on Parathyroid Hormone (PTH 1-84), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Parathyroid Hormone (PTH 1-84) group a baseline to be compared against.
What Was Measured
The effects of vitamin D supplementation in healthy prepubertal children on physiologic outcomes have not been investigated.
PubMed files the paper under topics including Absorption, Calcium, Dietary, Cholecalciferol, Diet, Dietary Supplements, Ethnicity and Linear Models.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Parathyroid Hormone (PTH 1-84) in 64 children.
Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2013 (The American journal of clinical nutrition), a journal based in United States.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.