Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis'.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The objectives of this study were to determine whether vitamin D supplementation to patients with tuberculosis (TB) could influence recovery.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults and adults, both men and women.

Assessments were performed at 4, 8 and 12 weeks.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Early secreted and T cell activated 6 kDa (ESAT6) and Mycobacterium tuberculosis sonicate (MTBs) antigen induced whole blood stimulated IFN-g responses were measured at 0 and 12 weeks.

Statistical comparisons between outcome variables at 0 and 12 weeks were performed using Student's t-test and Chi2 tests.

What Was Measured

The subject headings attached to it are Antigens, Bacterial, Bacterial Proteins, Dietary Supplements, Interferon-gamma, Mycobacterium tuberculosis, Tuberculosis, Pulmonary and Vitamin D.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2013 (BMC infectious diseases), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.