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Effects of vitamin D supplementation in older African American women.
Plain-language guide to PMID 23386641 (2013): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 23386641
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2013
- Study type
- Randomized Controlled Trial
- Authors
- Gallagher JC et al. (4 authors)
- DOI
- 10.1210/jc.2012-3106
- Registered trial
- NCT00472823
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The results can be used to estimate the Recommended Dietary Allowance (RDA).
Why It Was Studied
Serum 25-hydroxyvitamin D (25OHD) is lower in women with darker skin color.
Is it due to lower skin production, lower absorption, or different metabolism of vitamin D?
Who Took Part
PubMed indexes the participants as middle-aged adults, older adults and people over 80, women only.
Participants were 110 healthy older African American women.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
This was a randomized, double-blind placebo trial at Creighton University Medical Center and Indiana University Medical Center.
What Was Measured
Topics PubMed links to this paper include Black or African American, Aging, Calcium, Dietary, Cholecalciferol, Parathyroid Hormone, Vitamin D and Vitamin D Deficiency.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2013 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.