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Effects of vitamin D supplementation in older African American women.

Plain-language guide to PMID 23386641 (2013): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID
23386641
Journal
The Journal of clinical endocrinology and metabolism
Year
2013
Study type
Randomized Controlled Trial
Authors
Gallagher JC et al. (4 authors)
DOI
10.1210/jc.2012-3106
Registered trial
NCT00472823

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The results can be used to estimate the Recommended Dietary Allowance (RDA).

Why It Was Studied

Serum 25-hydroxyvitamin D (25OHD) is lower in women with darker skin color.

Is it due to lower skin production, lower absorption, or different metabolism of vitamin D?

Who Took Part

PubMed indexes the participants as middle-aged adults, older adults and people over 80, women only.

Participants were 110 healthy older African American women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

This was a randomized, double-blind placebo trial at Creighton University Medical Center and Indiana University Medical Center.

What Was Measured

Topics PubMed links to this paper include Black or African American, Aging, Calcium, Dietary, Cholecalciferol, Parathyroid Hormone, Vitamin D and Vitamin D Deficiency.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2013 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.