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Impact of vitamin D fortified milk supplementation on vitamin D status of healthy school children aged 10-14 years.

Plain-language guide to PMID 23460234 (2013): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 776 subjects.

Key Facts

PMID
23460234
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Year
2013
Study type
Randomized Controlled Trial
Authors
Khadgawat R et al. (10 authors)
DOI
10.1007/s00198-013-2306-9

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

To assess the effect of vitamin D fortified milk on serum 25 hydroxy vitamin D [S.25(OH)D] levels, the researchers carried out a prospective double-blind randomized control trial in apparently healthy school children, aged 10-14 years.

Why It Was Studied

Vitamin D deficiency is a major public health problem, needing immediate attention.

Vitamin D deficiency among school children and adolescents is a well-documented major public health problem, needing immediate attention.

Who Took Part

According to the abstract, 776 subjects were involved.

The age groups tagged for this paper are children and teenagers, both men and women.

Of 776 subjects recruited out of 796 who consented, 713 (boys-300; girls-413) completed the study.

Subjects were randomized into three groups.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

The subjects were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the subjects and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Serum calcium, phosphate, alkaline phosphatase, S.25(OH)D, and urinary calcium/creatinine ratio were estimated at baseline and after supplementation.

What Was Measured

Topics PubMed links to this paper include Cholecalciferol, Food, Fortified, India, Milk, Vitamin D and Vitamin D Deficiency.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 776 subjects.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2013 (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.