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Effects of recombinant human growth hormone for 1 year on body composition and muscle strength in children on long-term steroid therapy: randomized controlled, delayed-start study.

Plain-language guide to PMID 23626006 (2013): pilot randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 30 children.

Key Facts

PMID
23626006
Journal
The Journal of clinical endocrinology and metabolism
Year
2013
Study type
Randomized Controlled Trial
Authors
Simon D et al. (13 authors)
DOI
10.1210/jc.2012-4201

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Their objective was to evaluate rhGH effects on muscle strength in children receiving long-term glucocorticoid therapy; effects on height SD score (SDS) and body composition were assessed also.

Why It Was Studied

Its effects on muscle strength are poorly evaluated.

Who Took Part

According to the abstract, 30 children were involved.

The age groups tagged for this paper are children and teenagers, both men and women.

Patients included 30 children with various diagnoses.

How the Study Was Run

The researchers set it up as a randomized and pilot study.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

It is described as a pilot, a small early test of whether a larger Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study would be practical.

What Was Measured

Its effects on muscle strength are poorly evaluated.

Topics PubMed links to this paper include Adolescent Development, Body Composition, Body Height, Child Development, Chronic Disease, Drug Monitoring and Glucocorticoids.

What This Means in Plain Language

The paper is a randomized and pilot study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 30 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2013 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.

Our Notes on the Compound

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.