The effect of intravenous magnesium sulfate on serum levels of N-terminal pro-brain natriuretic peptide (NT pro-BNP) in elective CABG with cardiopulmonary bypass

What Was Tested

This randomized controlled trial paper looks at BNP (Nesiritide).

The researchers performed this study to assess the effect of MgSO4 solution on NT Pro-BNP levels in patients undergoing CABG with CPB.

Why It Was Studied

Nowadays, many patients undergo coronary artery bypass grafting (CABG) with a cardiopulmonary bypass (CPB); while a number of therapeutic agents have been used to suppress its related inflammatory process.

Magnesium sulfate (MgSO4) solution has been used as an anti-inflammatory agent.

Who Took Part

The study group was 88 patients.

PubMed indexes the participants as middle-aged adults.

In a double-blind clinical trial, after IRB approval for ethical considerations, during a 12-month period, 88 adult patients aged 40-70 years qualified for the study after inclusion and exclusion criteria were considered.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The patients were allocated by chance, so the BNP (Nesiritide) group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received BNP (Nesiritide).

The comparison arm used a placebo, so changes seen with BNP (Nesiritide) could be set against what happens without it.

The methods mention a period of 12 months.

The results were compared using a Student's t-test.

What Was Measured

PubMed files the paper under topics including Administration, Intravenous, Biomarkers, Cardiopulmonary Bypass, Coronary Artery Bypass, Elective Surgical Procedures, Magnesium Sulfate and Natriuretic Peptide, Brain.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of BNP (Nesiritide) in 88 patients over 12 months.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2013 (Journal of anesthesia), a journal based in Japan.

More context: the BNP (Nesiritide) compound page, all human trials.