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Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine
Plain-language guide to PMID 23786655 (2013): double-blind randomized controlled trial study of Vasopressin.
Key Facts
- PMID
- 23786655
- Journal
- Critical care (London, England)
- Year
- 2013
- Study type
- Randomized Controlled Trial
- Authors
- Mehta S et al. (19 authors)
- DOI
- 10.1186/cc12789
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Vasopressin.
Cardiac troponins are sensitive and specific biomarkers of myocardial necrosis.
The researchers evaluated troponin, CK, and ECG abnormalities in patients with septic shock and compared the effect of vasopressin (VP) versus norepinephrine (NE) on troponin, CK, and ECGs.
Who Took Part
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
Two physician readers, blinded to patient data and drug, independently interpreted ECGs.
How the Study Was Run
The design is described as randomized, double-blind and open-label.
Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Vasopressin.
Nothing was hidden in this open-label Vasopressin study: the participants and staff both knew the treatment.
This was a prospective substudy of a randomized trial.
Troponin I/T, CK, and CK-MB were measured, and 12-lead ECGs were recorded before study drug, and 6 hours, 2 days, and 4 days after study-drug initiation.
What Was Measured
The researchers evaluated troponin, CK, and ECG abnormalities in patients with septic shock and compared the effect of vasopressin (VP) versus norepinephrine (NE) on troponin, CK, and ECGs.
PubMed files the paper under topics including Biomarkers, Electrocardiography, Myocardial Ischemia, Norepinephrine, Shock, Septic, Troponin T and Vasopressins.
What This Means in Plain Language
The paper is a randomized, double-blind and open-label study of Vasopressin.
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2013 (Critical care (London, England)), a journal based in England.
More context: the Vasopressin compound page, all human trials.
Our Notes on the Compound
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.