Associations of IGF-1 gene variants and milk protein intake with IGF-I concentrations in infants at age 6 months - results from a randomized clinical trial

What Was Tested

Researchers studied IGF-1 LR3 in this randomized controlled trial publication.

The interplay of genetic and nutritional regulation of the insulin-like growth factor-I axis in children is unclear.

Who Took Part

The study group was 588 infants.

The age groups tagged for this paper are infants, both men and women.

How the Study Was Run

In design terms this was a randomized and multicenter study.

Random assignment meant chance, not the researchers, decided who got IGF-1 LR3 and who got the comparison, which limits bias.

Running at several centres spread the IGF-1 LR3 study over different clinics and patient groups.

Eight single nucleotide polymorphisms (SNPs) of the IGF-1-(rs6214, rs1520220, rs978458, rs7136446, rs10735380, rs2195239, rs35767, and rs35766) and two of the IGFBP-3-(rs1496495, rs6670) gene were analyzed.

Serum levels of total and free IGF-I, IGFBP-3 and the molar ratio IGF-1/IGFBP-3 at age 6 months were regressed on determined SNPs and feeding groups in 501 infants.

What Was Measured

Topics PubMed links to this paper include Age Factors, Breast Feeding, Eating, Genetic Association Studies, Infant Formula, Infant Nutritional Physiological Phenomena and Insulin-Like Growth Factor I.

The authors tagged it with the keywords European Childhood Obesity Trial Study, IGF-1 gene, IGF-I concentration, IGFBP-3 variants, Protein formula and Randomized clinical trial.

What This Means in Plain Language

The paper is a randomized and multicenter study of IGF-1 LR3 in 588 infants.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2013 (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society), a journal based in Scotland.

More context: the IGF-1 LR3 compound page, all human trials.