Effect of vitamin D replacement on hip structural geometry in adolescents: a randomized controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Analysis of Covariance (ANCOVA) was used to examine group differences for changes of bone structural parameters.

Why It Was Studied

This study investigated the impact of vitamin D on hip geometric dimensions from DXA-derived hip structural analyses in adolescents who participated in the trial.

Who Took Part

The abstract describes 167 girls taking part.

PubMed indexes the participants as teenagers, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the girls nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

DXA images were obtained at baseline and one year, and hip images were analyzed using the hip structural analysis (HSA) software to derive parameters of bone geometry.

These include outer diameter (OD), cross sectional area (CSA), section modulus (Z), and buckling ratio (BR) at the narrow neck (NN), intertrochanteric (IT), and shaft (S) regions.

What Was Measured

Topics PubMed links to this paper include Bone Density, Cholecalciferol, Femur, Hip Joint and Pelvic Bones.

The authors tagged it with the keywords Adolescence, Gender, Hip structural analysis, Lean mass, Randomized trial and Vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 167 girls.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2013 (Bone), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.